This website is a collaborative initiative of basic scientists, doctors and producers in the field of tumormarkers. On this website the members of the EGTM try to provide information for both patients and professionals on the interpretation of the laboratory results on tumormarkers.  
We try to achieve this goal by providing compact guidelines for professionals and additional explanatory texts that can be used by patients to discuss with their doctors.
On the other hand doctors may find these guidelines on tumormarkers also usefull to explain to their patients how and why they use tumormarkers in some conditions but not in other.


The European Group on Tumor Markers (EGTM) is an ad hoc group of European-based clinical (bio)chemists, pathologists, physicians, surgeons and scientists from the diagnostics industry with an interest in tumor markers.

Amongst its main aims are:

  • Publication of guidelines for the clinical application of tumor markers,
  • Education of healthcare professional on the optimum uses of tumor markers and
  • Organization of educational courses on the uses of tumor markers

Board Members

prof.dr R. Klapdor, Honorary Chairman
dr Rafael Molina , Chairman
dr Josep Marie Auge, Secretary
dr M. Nap, Treasurer (Vacancy)
dr G. Sölétormos, Member
prof. V. Barak, Member
prof Dr Joe Duffy, Member


European scientists from both hospital or university laboratories and from companies involved in the development of tumour marker tests, have been working together for several years in an informal group originating from the "Hamburg Symposia".

EGTM Publications: 2003-2018


  1. Duffy MJ, van Dalen A, Haglund L, Klapdor R, Lamerz R, Nilsson O, Sturgeon C, Topolcan O. Clinical Utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) Guidelines. Eur J Cancer 2003;39:718.
  2. Molina R, Barak V, van Dalen A, Duffy MJ, Einarsson R, Gion M, Goike H, Lamerz R, Nap M, Soletormos G, Stieber P. Tumor markers in breast cancer: European Group on Tumor Markers Recommendations. Tumor Biol 2005;26:281-293.
  3. Duffy MJ, Bonfrer JM, Kulpa J, Rustin GJS, Soletormos G, Torre GC, Tuxen M, Zwirner M. CA 125 in ovarian cancer: Eupopean Group on Tumor Markers guidelines for clinical use. Int J Gynecol Cancer 2005;15:679-691.
  4. Sölétormos G, Semjonow A, Sibley PE, Lamerz R, Petersen PH, Albrecht W, Bialk P, Gion M, Junker F, Schmid HP, Van Poppel H. Biological variation of total prostate-specific antigen: a survey of published estimates and consequences for clinical practice. Clin Chem. 2005;51:1342-51.
  5. Duffy MJ, van Dalen A, Haglund C, Hansson L, Holinski-Feder E, Klapdor R, Lamerz R, Peltomaki P, Sturgeon C, Topolcan O. Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use. Eur J Cancer. 2007;43:1348-60.
  6. Duffy MJ, Sturgeon C, Lamerz R, Haglund C, Holubec VL, Klapdor R, Nicolini A, Topolcan O, Heinemann V. Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report. Ann Oncology 2010;21:441-447.
  7. Duffy MJ, van Rossum LG, van Turenhout ST, Malminiemi O, Sturgeon C, Lamerz R, Nicolini A, Haglund C, Holubec L, Fraser CG, Halloran SP. Use of faecal markers in screening for colorectal neoplasia: a European group on tumor markers position paper. Int J Cancer 2011; 128:3-11.
  8. Sölétormos G, Duffy MJ, Hayes DF, Sturgeon CM, Barak V, Bossuyt PM, Diamandis EP, Gion M, Hyltoft-Petersen P, Lamerz RM, Nielsen DL, Sibley P, Tholander B, Tuxen MK, Bonfrer JM. Design of tumor biomarker-monitoring trials: a proposal by the European Group on Tumor Markers. Clin Chem. 2013;59:52-9.
  9. Duffy MJ, Lamerz R, Haglund C, Nicolini A, Kalousová M, Holubec L, Sturgeon C. Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update. Int J Cancer. 2014 Jun 1;134(11):2513-22.
  10. Duffy MJ, Sturgeon CM, Sölétormos G, Barak V, Molina R, Hayes DF, Diamandis EP, Bossuyt PM. Validation of new cancer biomarkers: a position statement from the European group on tumor markers. Clin Chem. 2015 Jun;61(6):809-20.
  11. Sölétormos G, Duffy MJ, Othman Abu Hassan S, Verheijen RH, Tholander B, Bast RC Jr, Gaarenstroom KN, Sturgeon CM, Bonfrer JM, Petersen PH, Troonen H, CarloTorre G, Kanty Kulpa J, Tuxen MK, Molina R. Clinical Use of Cancer Biomarkers in Epithelial Ovarian Cancer: Updated Guidelines From the European Group on Tumor Markers. Int J Gynecol Cancer. 2016 Jan;26(1):43-51.
  12. Duffy MJ, Harbeck N, Nap M, Molina R, Nicolini A, Senkus E, Cardoso F. Clinical use of biomarkers in breast cancer: updated guidelines from the European Group on Tumor Markers (EGTM). Eur J Cancer 2017; 83:258-265.